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M9480495.TXT
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1994-08-20
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Document 0495
DOCN M9480495
TI Spatial discontinuities in human immunodeficiency virus type 1
quasispecies derived from epidermal Langerhans cells of a patient with
AIDS and evidence for double infection.
DT 9410
AU Sala M; Zambruno G; Vartanian JP; Marconi A; Bertazzoni U; Wain-Hobson
S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,;
France.
SO J Virol. 1994 Aug;68(8):5280-3. Unique Identifier : AIDSLINE
MED/94309197
AB A nonhomogeneous spatial distribution of human immunodeficiency virus
type 1 quasispecies was observed for epidermal Langerhans cells purified
from skin patches taken from a patient with AIDS soon after death. Each
patch presented a unique collection of sequences, distinct from those of
juxtaposed patches or those derived from the other leg. Infection of
Langerhans cells by virus from underlying T cells in the dermis might
explain this partition. The analysis revealed the presence of two
distinct cocirculating viral strains, indicating double infection.
DE Acquired Immunodeficiency Syndrome/*MICROBIOLOGY Amino Acid Sequence
Base Sequence DNA, Viral Human
HIV-1/*CLASSIFICATION/GENETICS/ISOLATION & PURIF Islets of
Langerhans/*MICROBIOLOGY Molecular Sequence Data Sequence Homology,
Amino Acid Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).